Cloma Pharma Methydrene EPH 25 Ephedra Pre Workout Review

Cloma Pharma Methydrene EPH 25 Ephedra Pre Workout Review

Cloma Pharma Methydrene EPH 25 Ephedra Pre Workout Review First Look:

The bright red sachet. The yellow panels. The serious and military looking typeface.

It all looks very dangerous. It looks almost illegal.

It look s effective…if you dare run the risk. Serious lifters only, bro.

But I needed it.

I had taken a week off the heavy lifting, only doing some accessory lifts, but nothing like I did tonight. My chest and shoulders plus bag took a hammering and I needed something to power me through.

took one look at this pre workout staring back at me on my desk and thought I would run the gauntlet.

Of all the pre workouts this looked the most serious. It looked like something issued to shock troops who known they only really have a 24 hour window to take the fight to the enemy and either beat them or be destroyed.

To put it bluntly, the tangy tangerine flavor did taste like something from a MRE pack.


Cyclic Adenosine Monophosphate (cAMP) – In cells the stimulatory effects of epinephrine are mediated through the activation of a second messenger known as cAMP (cyclic adenosine monophosphate).

The activation of this molecule results in the stimulation of cell-signaling pathways that act to increase heart rate, to dilate blood vessels in skeletal muscle, and to break down glycogen to glucose in the liver.

Leucine – Leucine is an activator of the protein known as mTOR, which then induces muscle protein synthesis.

Yohimbe – Related to Yohimbine, Yohimbe is a powerful stimulant and used to increase fat loss as well as assist with erectile dysfunction. Can cause a host of other problems though, this is in out supplements to avoid list.

Supplementation with yohimbine combined with resistance training does not significantly alter the body mass, muscle mass, or performance indicators.

Ephedra Nevadensi – This is not Ephadrine.

This is a plant used in a tea to cure sexually transmitted diseases. It doesn’t work though, shame.

Dimethylaminoethanol DMAE – This compound can help with cognitive impairment, however, results from studies are a bit patchy. This is not classified for use as a food additive in the USA. Has been marketed as DEANOL.

L-Citrulline – This is used as a sports performance and cardiovascular health supplement. L-Citrulline supplementation results in reduced fatigue and improved endurance for both aerobic and anaerobic prolonged exercise. An increase in growth hormone has been noted with exercise, but not at rest.

L-citrulline boosts nitric oxide production in the body. Nitric oxide helps your arteries relax and work better, which improves blood flow throughout your body.

Supplementing can help lower blood pressure in people with prehypertension.

Alpha GPC – Appears to have cognitive-enhancing properties (no human evidence exists to support this in otherwise-healthy youth, but it does have support in rodents) and attenuate the rate of cognitive decline in the elderly.

In regards to reducing the rate of cognitive decline, alpha-GPC at high doses (1,200 mg) does appear to be somewhat effective – we do not know the exact amount here, it is likely to be low though.

Arginine-alpha-ketoglutarate (AAKG) – Tests on supplementation draw no real benefit that would not be found from resistance training itself.

Creatine – A well regarded supplement.

Supplementation increases creatine storage and promotes a faster regeneration of adenosine triphosphate between high intensity exercises. These improved outcomes will increase performance and promote greater training adaptations.

B-phenylethylamine hcl –  Used for treating depression and increasing athletic performance. No evidence to substantiate these claims.

Limited supplemental usage due to being rapidly broken down into inactive components.

Caffeine – It stimulates the central nervous system (CNS), heart, muscles, and the centers that control blood pressure to give you an extra boost and hit that PB.

Caffeine Anhydrous is the purest form of caffeine so always look out for it.

This is found in 4 Gauge which is the best pre-workout.

Schisandrae Chinensis (Five Flavor Berry) – This is claimed to have many uses, however, as with many plants there’s a real lack of evidence to back these claims up.

As per usual treatment of STI’s is supposedly plausible but any performance enhancement is very doubtful. If it was, we would definitely have the evidence by now.


1 sachet with water which is a low 3675mg.

This is not competitive compared to the best pre workout supplements that offer around four times as much.

The sachet was tangy tangerine flavor which tasted like the armpit of an ISIS terrorist.

All I could do was throw it back.

Effects & Benefits:

There are 6 potentially beneficial ingredients present.

They crop up in most of the pre workout that are know to be effective.

Items such as Caffeine and Citrulline can help with alertness, concentration, energy and in the case of citrulline increase nitric oxide production.

Leucine helps with muscle protein synthesis.

Creatine is widely known for its strength and muscular size benefits, however, for the best results this should be supplemented regularly.

cAMP is not quite as often included in supplements but can increase the heart rate as well as dilate blood vessels, this means more oxygen can get to the muscles and more waste can be taken away to be processed.

Yohimbe is a well known powerful stimulant…

How did it feel?

I didn’t feel anything at all.

For all of its serious and almost alarming packet there was nothing to warrant it.

The overall dose is really low too, it’s only about a quarter of what I am normally accustomed to.

The proprietary blend is most likely hiding the actual low content offered of each ingredient included within that blend. This is the problem with proprietary blends.

Check out my thoughts on the video below.

READ: Read about our favorite pre workout that turned me in to a beast on the rugby pitch



Well it just didn’t work. This is most likely due to the low overall dose and the fact there is a proprietary blend hiding the exact amount included for each ingredient. ie there’s very little included.

So, this is problem the reason behind the lack of effectiveness from the beneficial ingredients.

However, there’s also a host of other ingredients that have no body of evidence to prove they are effective in tests.

Including Ephedra Nevadensi is merely a way to fool people in to thinking this is ephedra…it isn’t.

DMAE doesn’t appear to really have any effects nor benefits.

Alpha GPC is extremely dose dependant and a high dose is required, only seems to be effective in the elderly and not youth.

The lack of evidence also spans across AAKG, B-phenylethylamine hcl and Schisandrae Chinensis too.

It is also worth mentioning that Yohimbe is potentially dangerous.

Cloma Pharma Methydrene EPH 25 Ephedra Pre Workout Review Conclusion:

What do we have presented before us then?

An under-dosed pre workout whereby only 6 ingredients which equates to 50% of the product have any value. However, we have no idea how much or how little of the ingredients are included.

In tests I felt nothing that wold suggest I had taken a pre workout supplement.

There’s just too many holes in this product.

A low dose, a proprietary blend and 6 other ingredients that are not proven to work.

The result is an ineffective and underwhelming pre workout in a sachet that is more effective than its contents.

Try one of these we have picked out for being the most effective and beneficial pre workout supplements.



Ben BA(Hons), PGCert

Ben established this site to be a free resource in 2015. Since then it has gained over half a million visits. He has always been interested in sport and he started playing rugby at the age of 6 represented his town, county and school. Ben also enjoys cycling, has started skiing and is in the Army Reserve representing his Regiment as part of the 150 Regimental Shooting Team. He holds a bachelor's and postgraduate degree in sport exercise & nutrition.

Leave a Reply

Your email address will not be published. Required fields are marked *

Verified by MonsterInsights